KMID : 1001020180160030119
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Journal of Urologic Oncology 2018 Volume.16 No. 3 p.119 ~ p.125
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Comparison of Prognosis in Types 1 and 2 Papillary Renal Cell Carcinoma and Clear Cell Renal Cell Carcinoma in T1 Stage
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Lee Jae-Hoon
Chae Han-Kyu Lee Won-Chul Nam Wook Lim Bum-Jin Choi Se-Young Kyung Yoon-Soo You Dal-San Jeong In-Gab Song Che-Ryn Hong Bum-Sik Hong Jun-Hyuk Ahn Han-Jong Kim Choung-Soo
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Abstract
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Purpose: We compared subtypes of papillary renal cell carcinoma (pRCC; types 1 and 2) and clear cell renal cell carcinoma (ccRCC) in patients with T1-stage RCC to analyze the impact of the subtype on oncological outcomes.
Materials and Methods: This paper reviewed 75 patients with pRCC and 252 patients with ccRCC at T1-stage from 1998?2012. Thus, we assessed the impact of subtype on oncologic outcomes among patients with T1-stage RCC. We used Kaplan-Meier analysis to estimate the overall survival and recurrence-free survival The median follow-up duration was 95 months (interquartile range, 75.4?119.3 months).
Results: The 5-year recurrence-free survivals of pRCC and ccRCC were 95.4% and 97.6%, respectively. pRCC is worse than ccRCC in terms of recurrence-free survival (p=0.008) and there was no significant difference in the overall survival between pRCC and ccRCC (p=0.32). In addition, there was no significant statistical difference between type 1 pRCC and type 2 pRCC in terms of either recurrence-free survival (p=0.526) or overall survival (p=0.701). Age (hazard ratio [HR], 1.069; p£¼0.001) and recurrence (HR, 4.93; p£¼0.001) were predictors of overall survival. Only tumor size (HR, 1.071; p=0.004) was predictors in the case of cancer specific survival in the multivariate analysis.
Conclusions: Among patients with T1-stage RCC, recurrence after surgery was more common in pRCC than ccRCC. The subtype of pRCC (types 1 and 2) had no impact on the recurrence-free survival or overall survival.
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KEYWORD
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Renal cell carcinoma, Histologic subtype, Recurrence, Survival, Prognosis
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